BCL2 and cancer: As an anti-apoptotic protein belonging to BCL2 family, MCL1 has recently been regarded as an important target for cancer therapy.36, 57 In this study, demethylzeylasteral is proved to cause cell cycle arrest at S phase and inducing apoptosis in melanoma cells by inhibiting MCL1, which indicates that MCL1 is involved in both cell cycle and apoptosis.