UV irradiation elicits a range of responses in the skin, including inflammatory and DNA damaging responses, which lead to the development of photoaging and skin cancer in chronically exposed skin.16 Of these, acute inflammatory reaction is mediated by the UV-induced release of proinflammatory cytokines, such as TNF-α, IL-6, and IL-8. This evidence concerns the gene CXCL8 and skin cancer.