Polycystic ovary syndrome (PCOS) is one of the most incident reproductive endocrine diseases, with a prevalence ranging from 5 to 10% in women of reproductive age.1 The typical characteristics of PCOS include polycystic ovaries, hyperandrogenism and anovulation.2 Although the pathogenesis of PCOS is complex and largely unknown, the syndromes are often associated with hormone disorders, such as decreased progesterone and increased testosterone, estrogen and luteinizing hormone (LH), etc.3 Progesterone is a steroid hormone secreted mainly by ovarian granulosa cells and luteal cells. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.