EGFR plays a critical role in cell growth and differentiation, and is involved in many reproductive processes, including implantation and decidualization.51 Ahmed et al.52 reported that EGFR was one of the most potent receptor-tyrosine kinases driving tumor proliferation, and PGRMC1 promoted several cancer phenotypes, at least in part, by binding EGFR and stabilizing plasma membrane pools of the receptor. Here, PGRMC1 is linked to cancer.