EphA2 includes both intact and cleaved forms secreted from cancer cells.9, 18, 24 In our preliminary results, high levels of EphA2 were detected frequently in serum from healthy donors (382±493 pg/ml, n=26) when we used mAb 46A1 that reacts with both soluble EphA2 fragments and the intact form (Supplementary Figure S2), whereas EphA2 values detected by mAb 76A1 were almost negligible (Supplementary Figure S2). This evidence concerns the gene EPHA2 and cancer.