However, MT1-MMP is usually expressed in activated stromal cells, such as myofibroblasts, invading endothelial cells, and monocytes.19, 20, 21 Furthermore, MT1-MMP is frequently overexpressed in cancer cells together with EphA2 as reported in many previous studies and in the Cancer Genome Atlas database (http://cancergenome.nih.gov/). The gene discussed is EPHA2; the disease is cancer.