FN1 and neoplasm: Although, fibroblasts secrete several growth factors (e.g., insulin-like growth factor 2, bone morphogenetic protein 4), cytokines (e.g., interleukin 6), chemokines (e.g., chemokine (C-X-C motif) ligand 1 (CXCL1), interleukin 8 (IL-8)) as well as important structural macromolecules (collagen, fibronectin, tenascin) forming the extracellular matrix (ECM), existing anti-tumor therapies are mainly focused on the possibility to modulate the incipient cancer cells which has not resulted in significantly improved survival [2,6].