In this study, LSS-11 significantly increased the levels of DR5 and cleaved PARP1 (Figure 2b), proteins mainly involved in death-receptor-mediated apoptosis [43], but did not affect mitochondria-associated Bax or Bcl2 proteins in paclitaxel-resistant lung cancer cells. The gene discussed is TNFRSF10B; the disease is lung carcinoma.