Furthermore, central nervous system(CNS) insulin resistance has been linked to cognitive impairment (Craft et al., 2013; De Felice, 2013), includingreduced performance on tests of episodic and working memory (Talbot et al., 2012) and impairedperformance on an episodic memory task that is linked to reduced activity in thecore neural network associated with memory recall (Cheke et al., 2017). The gene discussed is INS; the disease is Cognitive impairment.