One tumor (T286) presented one POLE missense mutation (c.857C>G, p.Pro286Arg) (Fig. 1A), and another tumor (T368) presented two POLE missense mutations (c.901G>A, p.Asp301Asn (Fig. 1B); and c.1376C>T, p.Ser459Phe (Fig. 1C)). The gene discussed is POLE; the disease is neoplasm.