Inhibition of autophagy through different mechanisms including calpain inhibitor [86], downregulation of heat shock protein B8 (HSPB8) [87], B cell lymphoma 2-interacting mediator of cell death (BIM) upregulation [90], tipifarnib [85], or (hydroxy)chloroquine [92, 93] increased BTZ sensitivity in a MM model. The gene discussed is CASC3; the disease is Miyoshi myopathy.