PNOC and migraine disorder: Recent findings showing the involvement of N/OFQ in inflammatory responses (Gavioli and Romão 2011) and the evidence for a role of NOP receptors and N/OFQ in the modulation of neurogenic inflammation, migraine (Tajti et al. 2015), and airway tone (Singh et al. 2016) led to the hypothesis that N/OFQ-NOP system might be an important drug target for analgesic drugs.