Huangyuan Li, at Fujian Medical University, China, and colleagues examined the effects of paraquat and MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine), two chemicals known to induce parkinsonism, in mice lacking Nrf2, a key mediator of antioxidant and anti-inflammatory responses. This evidence concerns the gene NFE2L2 and Parkinson disease.