TP53 and neoplasm: This gene plays a role on tumor suppression processes including cell cycle arrest and apoptosis.2 Mutation in p53 gene leading to the loss of wild-type p53 activity is frequently detected in many different tumor types.3 Enhancing of invasiveness, attenuating of apoptosis and increasing of genomic instability are generally occurred after mutation of p53.4 The p53-mutant cancer may not be treated with the same agent as p53 wild type cancer.