TP53 and malignant colon neoplasm: Surgery, chemotherapeutic drugs and radiation therapy are some of the cancer therapies that frequently be used to treat colon cancer patient.5 Cisplatin and its derivatives are the effective DNA-damaging anti-tumor agent for various human cancers, including colon cancer.6 The p53 protein is stabilized and its level increases in response to various DNA damaging agents, including cisplatin.