MLH1 and colorectal cancer: For example, the mutation or hypermethylation of hMLH1 gene can cause the colorectal cancer.61 5-Aza-2'-deoxycytidine (decitabine; DAC) used for the inhibition of DNA methylation, which has no effect on the tumor growth, but it sensitizes the tumor to other drugs such as cisplatin and carboplatin.