CYP19A1 and rheumatoid arthritis: An acute decline in oestrogens bioavailability is thought to be responsible of the proinflammatory effect resulting in increased overall risk of RA development (postmenopausal period, early menopausal age, postpartum, use of oestrogens inhibiting drugs) and is already known that inflammatory mediators are thereby responsible for aromatase activation, conversely resulting in increased conversion of androgens to oestrogens.16