CASP3 and cancer: Therefore, we were able show how EA in combination with radiation able to create an imbalance between cell survival and apoptosis pathway and shifted the cancer cells towards apoptosis by upregulating p53-p21-Bax-active caspase 3 axis, simultaneously by downregulating NF-κB-COX-2-BCL2-IL6-STAT3 axis (Fig. 8).