More specifically, the efficiency of CPB depends on cytotoxic CD8+ T-cell (CTL) recognition of cancer-specific antigens presented on human leukocyte antigen (HLA) class I complexes, which are composed of a heavy-chain and beta-2-microglobulin (B2M), a crucial factor required for to the assembly of all HLA class I complexes and for the stable presentation of antigens by the tumor cells7. Here, B2M is linked to cancer.