With the use of select findings from 6 previously published reports from the BRINDA project (25–30), this review summarizes the magnitude of the effect of AP proteins (specifically CRP and AGP) on iron-status indicators (SF and sTfR concentrations and TBI), and assesses the potential impact of the use of regression to adjust for inflammation on estimates of ID in both low– and high–infection-burden settings. The gene discussed is DHCR7-DT; the disease is infection.