In the present study, we found decreased CD74 expression in B cells from females carrying the risk allele of rs10036748 (proxy SNP for the SLE- and pSS-associated rs7708392 in the TNIP1 locus), which functionally may relate to an altered regulation of the peptide repertoire presented by MHC II. The gene discussed is CD74; the disease is systemic lupus erythematosus.