For this diagnostic process, access to a variety of imaging modalities to differentiate Alzheimer’s disease from other neurodegenerative conditions would be necessary—structural imaging (MRI, CT), FDG-PET, DAT, as well as amyloid and possibly tau PET (plus access to radiolabelled tracers)—plus neuroradiological and nuclear medicine expertise for the interpretation of these imaging modalities and their contextualisation alongside other assessments. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.