This study integrated all available studies involving a large population showed that immunohistochemical detection of p53 protein expression was significantly higher in UC with CRC than in UC with dysplasia, higher in UC with dysplasia than in UC without dysplasia and carcinoma, and higher in UC without dysplasia and carcinoma than in normal tissue samples, which suggested that p53 expression was closely linked to UC-CRC carcinogenesis and the progression of UC with dysplasia. This evidence concerns the gene TP53 and carcinoma.