In 2006, De Soto evaluated the sensitivity of multiple cell lines (non-cancerous mouse embryonic stem cells and hamster cells; human and mouse breast tumor cells) with BRCA1 or BRCA2 deficiency to three PARP1 inhibitors (NU1025, 3-aminobenzamide, and AG14361) [29]. This evidence concerns the gene PARP1 and breast neoplasm.