These cells have been engineered to produce anti-angiogenic factors in different tumor models such as soluble VEGF receptor-1 (sFLT-1) in Lewis lung cancer [120], endostatin in colorectal carcinoma [121], throspondin-1 (TSP-1) in glioblastoma [122] and pigment epithelium-derived factor (PEDF) in prostate carinoma [123]. The gene discussed is SERPINF1; the disease is colorectal carcinoma.