Recently, on this topic we reported that bone-marrow MSCs (BM-MSCs) derived from patients induced the metastatic phenotype of osteosarcoma and hepatocellular carcinoma through stromal derived factor 1 (SDF-1)-C-X-C-Chemokine receptor type 4 (CXCR4) axis and also through the aquaporin 1 (AQP1) membrane channel [6, 7]. This evidence concerns the gene CXCL12 and osteosarcoma.