MEG3 and osteosarcoma: The methylation pattern in the MEG3 DMR as well as the expression profile of miRNAs in the region can distinguish high-aggressiveness versus low-aggressiveness osteosarcoma cell lines, and the levels of miR-495, miR-329, miR-487b, miR-410, and miR-656 can predict the outcome of patients with osteosarcoma [107].