At the moment the very high risk groups for pancreatic cancer are still patients of AJ descent, as approximately 1.1% of the Jewish population carry a BRCA1 founder mutation and 1.1% carry a BRCA2 founder mutation [43], and families with ≥ 3 first- or second-degree relatives with PDAC. Here, BRCA2 is linked to familial pancreatic carcinoma.