A high-throughput isobaric tagging for relative and absolute quantitation (iTRAQ)-based proteomics revealed that the expression of S100A4 was higher in PGCCs with their daughter cells than that in the control cells [191], indicating that S100A4 could be involved in PGCC formation, EMT, and asymmetric cell division, subsequently, affecting tumor progression and metastasis. The gene discussed is S100A4; the disease is neoplasm.