Additionally, activation of the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/p70S6K signaling is reported to mediate S100A4-induced cell viability, migration, vascular endothelial growth factor (VEGF) expression, and E-cadherin downregulation in CRC [97]. The gene discussed is S100A4; the disease is colorectal carcinoma.