CP1, the polysaccharide fraction extracted from Coix lachryma-jobi can induce cells to undergo apoptosis, repress cell migration and invasion, and downregulate the levels of S100A4 mRNA and protein in NSCLC cells, which could be due to CP1 interaction with the binding site of S100A4/NMIIA pocket but not the dimerization site of S100A4 [182]. This evidence concerns the gene S100A4 and non-small cell lung carcinoma.