S100A4 can also promote the cancer stem cell (CSC)-like properties in gastric cancer cells by the enhancement of growth differentiation factor 15 (GDF15) expression, i.e., S100A4 binds to the GDF15 promoter to induce CSC-like properties in gastric cancer cells, including the formation of spheroid and soft-agar colonies [91]. This evidence concerns the gene GDF15 and gastric cancer.