S100A4 and neoplasm: Calcimycin was identified as a transcriptional inhibitor of the S100A4-promoter activity after a high-throughput screen of small-molecule compounds and was able to inhibit the expression of S100A4 mRNA and protein in a dose- and time-dependent manner followed by the suppression of β-catenin expression and impairment of S100A4-induced tumor cell motility and metastasis [102].