The S100A4/NF-κB/MMP9 axis had a significant correlation with NSCLC invasiveness and metastasis; while the S100A4 expression depleted by shRNA, inhibited NF-κB activity and TNF-α-induced MMP9 expression, the inhibition of the NF-κB/MMP9 axis decreased lymphovascular invasion and increased NSCLC overall survival [141]. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.