Propofol, an anesthesia agent, exhibits anticancer properties in several human cancers by the inhibition of invasion and angiogenesis brought about by the induction of apoptosis in human ESCC cells in a dose and time-dependent manner through the regulation of S100A4, whereas pre-transfection of S100A4 cDNA blocked the effects of propofol-induced apoptosis by promotion of tumor cell invasion and angiogenesis in ESCC cells [183]. Here, S100A4 is linked to cancer.