While, S100A4 has been known to be an EMT-promoting protein by causing the downregulation of E-cadherin expression [51] and modulation of the mesenchymal phenotype of the EMT in epithelial cells for tumor progression and metastasis, matrix metalloproteinases (MMPs) and integrins also are known to facilitate cell invasion and metastasis by the induction of the EMT [52, 53]. This evidence concerns the gene S100A4 and neoplasm.