GPT and Hyponatremia: Grade 3 treatment-related AEs at DL1 were diarrhea (n = 2), hyponatremia (n = 1), fatigue (n = 1), and AST/ALT elevation (n = 1) whereas at DL2, nausea, vomiting, abdominal pain, hyponatremia and pneumonitis (n = 1, for each individual AE).