Consistent with the data about esophageal cancer, medullary thyroid carcinoma, pancreatic ductal adenocarcinoma, colorectal cancer, renal clear cell carcinoma, astrocytoma, prostate cancer, lung cancer and hepatocellular carcinoma [35, 43–50], we found up-regulated GRP78 expression in gastric cancer, compared with gastric mucosa at both mRNA and protein levels, suggesting that GRP78 hyperexpression was positively linked to gastric carcinogenesis. This evidence concerns the gene HSPA5 and hepatocellular carcinoma.