In the present study, the co-dominant model, dominant model, and allele model results suggest that subjects carrying the T allele have higher prostate cancer risk compared to those with the C allele, which could be because T alternation in rs243865 could decrease promoter activity in two different luciferase reporter gene constructs: one in the context of the Sp1 regulatory element and the other in the background of the native MMP2 promoter [25]. Here, SP1 is linked to Familial prostate cancer.