Whereas Masugi et al. [38] found that 89% of colorectal carcinomas exhibited high tumor PD-L1 expression Lee et al. and Rosenbaum et al. reported on low levels of PD-L1 expression in colorectal cancer (5% and 9%, respectively) [39, 40] again possibly due to differences in methods applied. This evidence concerns the gene CD274 and colorectal cancer.