Finally, two non-synonymous polymorphisms in AD with potential functional impact were chosen to evaluate their possible effects on GRK5 function and their association with AD: cDNA nucleotide position 122 A/T changes glutamine (Gln) to leucine (Leu) at amino acid 41 (rs2230345) and nucleotide 840 G/A changes arginine (Arg) to histidine (His) at amino acid 304 (rs2230349) [25, 26]. The gene discussed is GRK5; the disease is Alzheimer disease.