Therefore, the combined use of binase and IFN would not only effectively eradicate HPV-positive cervical cancer cells, but also prevent malignancy due to HPV-related lesions such as genital warts, cervical intraepithelial neoplasia, as well as post-surgical re-infection with high risk HPVs. This evidence concerns the gene IFNA1 and cervical intraepithelial neoplasia.