The mutational profile of HNSCC is characterized by recurrent alterations in tumor suppressor genes (of the 15 most common HNSCC mutated genes only HRAS and PIK3CA are oncogenes) where singular hot spots are infrequent and the mutational spectra covers various exon regions and/or specific functional protein coding domains [25]. Here, HRAS is linked to head and neck squamous cell carcinoma.