Indeed, both the long non-coding RNA, CDKN2B-AS ANRIL, and p15 INK4B are induced in HPV+ cervical carcinomas with respect to HPV- tumors and normal control tissue; similarly, high levels of both CDKN2B encoded genes are expressed in HPV+ head and neck cancers (Figure 2). This evidence concerns the gene CDKN2B-AS1 and head and neck cancer.