One small study reported that expression of both KDM6A and KDM6B is substantially reduced in HPV+ mildly dysplastic lesions; however, stepwise increases were observed for both demethylases in precancerous lesions and cervical carcinoma, such that the carcinomas express both demethylases at levels similar to normal control tissues [52]. This evidence concerns the gene MBD2 and cervical carcinoma.