With respect to lung cancer, recent studies have demonstrated that treatment with paclitaxel induced a greater ALDH1+ve CSC population in H460 and H1299 lung cancer cell lines, while treatment with the selective CSC inhibitor, salinomycin, decreased the presence of the ALDH1+ve population and reduced the tumorsphere formation potential of these cells, but had no effect on the ALDH1-ve population [28]. The gene discussed is ALDH1A1; the disease is lung cancer.