Angiotensin (Ang) II, a main biological peptide of RAS, plays an essential role in myocardial interstitial fibrosis by enhancing activation of connective tissue growth factor (CTGF)-fractalkine (FKN) signaling, contributing to increased myocardial hypertrophy, dysfunction and injury [10, 11]. The gene discussed is CX3CL1; the disease is cardiac hypertrophy.