Compared with pAAV-GFP-treated hypertensive rats, administration of pAAV-SIRT6 significantly prevented Ang II-mediated pressor response at post 4-week treatment (Figure 1A) and myocardial hypertrophy (Figure 7C) in hypertensive rats with upregulated cardiac levels of ACE2 (Figure 1D) and pAMPKα (Figures 6A, 6B). The gene discussed is SIRT6; the disease is cardiac hypertrophy.