CASP3 and neoplasm: Further, we found that [10]-gingerol promotes cell death primarily via induction of caspase-dependent apoptosis, evidenced by a significant increase in caspase-3 activation throughout primary tumours, cleavage of caspase-3 and −9 in vitro, or accumulation of cells in sub-G1, TUNEL positivity and concentration-dependent increase in annexin-V staining in vitro.