In particular, ZEB1, a key mediator of EMT and E-cadherin suppression in lung cancer cells [21, 22], recruits the traditional corepressor C-terminal-binding protein (CtBP) to the promoter of E-cadherin gene, and the histone modifying complexes bound to CtBP then impose histone repressive marks leading to transcriptional repression [23, 29]. The gene discussed is CTBP1; the disease is lung cancer.