CD274 and cancer: In just 3 years the U.S. Food and Drug Administration (FDA) has approved two anti PD-1 antibodies: nivolumab (Opdivo, Bristol-Myers Squibb) and pembrolizumab (Keytruda, Merck), and three anti-PD-L1 antibodies, atezolizumab (Tecentriq, Genentech/Roche), durvalumab (Imfinzi, AstraZeneca) and avelumab (Bavencio, EMD Serono, Inc.), rising hope in patients suffering from cancers, which were deadly prior to the introduction of checkpoint inhibitors.