We found that the expression of SRPK1 or IGF1R was not correlated to age or gender, and SRPK1 or IGF1R expression was closely correlated to histological differentiation (p = 0.018, p = 0.001), lymph node metastasis (p < 0.001, p = 0.016) and UICC stage (p < 0.000, p = 0.037) (Table 1). This evidence concerns the gene SRPK1 and metastatic malignant neoplasm in the lymph nodes.