Finally, we applied the PLA method to NSCLC tissue obtained by transbronchial lung biopsy from 15 patients harboring EGFR mutations and 14 patients WT for EGFR. Consistent with the cell line data, the extent of EGFR homodimerization was significantly higher in tumors harboring EGFR mutations than in those WT for EGFR (Figure 3). Here, EGFR is linked to non-small cell lung carcinoma.