In esophageal tumors, there was only a significant interaction for CD3+ cells and CD20+ cells (pinteraction =0.028), whereas in gastric tumors, significant interactions were observed for CD3+, CD8+ and FoxP3+ cells with CD20+ cells in relation to OS (pinteraction =0.012, 0.009 and 0.007, respectively). The gene discussed is FOXP3; the disease is neoplasm of esophagus.