Emerging evidence demonstrate that the HBX has been shown capable of transactivating many different viral and cellular promoters and high HBXIP expression was predominantly observed in breast cancer tissues instead of the adjacent normal breast tissues and HBXIP promotes the proliferation and migration of breast cancer cells and plays crucial roles in the development of breast cancer, serving as a key oncoprotein in cancer [22–30]. Here, LAMTOR5 is linked to breast cancer.