We report here that global deletion of SR-B1 protects mice against B16F10 melanoma tumor growth and myeloid-specific deletion of either ABCA1 or ABCG1, or the combined myeloid deletion of both ABCA1 and ABCG1 in somatic cells, protects mice against B16F10 melanoma tumor growth, with comparable results for ABCA1 in a syngeneic MB49 murine bladder cancer model. The gene discussed is ABCA1; the disease is neoplasm.