OCT4 can be regarded as an oncogene with complex mechanisms in its role in tumor development and progression; besides its role in regulating survivin and CCND1-related signaling pathways (as our study showed), OCT4 may promote the malignant progression of tumors by regulating the Wnt, Hedgehog, and transforming growth factor (TGF)-β signaling pathways [9]. This evidence concerns the gene POU5F1 and neoplasm.