Actually, several lncRNAs including H19 [10, 11], MALAT1 [12, 13], UCA1 [14, 15], HOTTIP [16], have been reported to be involved in the chemoresistance of various kinds of malignant tumors, such as bladder cancer, pancreatic cancer, glioblastoma, and so on. This evidence concerns the gene HOTTIP and pancreatic neoplasm.