HOTTIP and familial pancreatic carcinoma: Actually, several lncRNAs including H19 [10, 11], MALAT1 [12, 13], UCA1 [14, 15], HOTTIP [16], have been reported to be involved in the chemoresistance of various kinds of malignant tumors, such as bladder cancer, pancreatic cancer, glioblastoma, and so on.