Twenty-one days after tumor detection, we found that tumor volumes (mean ± S.D.)(32.92±41.19 mm3; n=6) for the AG488 group were significantly lower, as well as those treated with the anti-VEGF antibody (15.56±17.17 mm3; n=5) and with TMZ (8.72±6.66 mm3; n=6) (p<0.0001 for all three agents), compared to untreated (87.42±115.60 mm3; n=8) and IgG (77.86±104.90 mm3; n=7) treatment groups. This evidence concerns the gene VEGFA and neoplasm.