For example, ccRCC is characterized by silencing of the VHL gene and alteration of the hypoxia-inducible factor pathway [15–17]; mutations of the MET and FH genes are commonly observed in type I and type II PCC, respectively [18, 19]; and abnormal TP53 and BHD genes have been implicated in Chromophobe [20]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.