Moreover, we also previously reported that PrPC is related to multi-drug-resistance with aberrant high expression in Adriamycin(ADR)-resistant gastric adenocarcinoma cell line SGC7901/ADR and Vincristine(VCR)-resistant cell line SGC7901/VCR, [10] which also displayed cross-resistance to other anticancer drugs [11]. This evidence concerns the gene PRNP and gastric adenocarcinoma.