To validate this speculation, we monitored the expression levels of CDK1 and iASPP in tissues derived from CRC patients at different stages, and different CRC cell lines; tested and verified the interaction between CDK1 and iASPP proteins; finally investigated the functional role of CDK1 and iASPP in regulating CRC cell proliferation through the p53 pathway, and in the prognosis of CRC patients. This evidence concerns the gene CDK1 and colorectal carcinoma.