TP53 and colorectal carcinoma: To validate this speculation, we monitored the expression levels of CDK1 and iASPP in tissues derived from CRC patients at different stages, and different CRC cell lines; tested and verified the interaction between CDK1 and iASPP proteins; finally investigated the functional role of CDK1 and iASPP in regulating CRC cell proliferation through the p53 pathway, and in the prognosis of CRC patients.