Interestingly, in absence of MYC/MYCN deregulation, in UW479, the inhibition of HIF-1α and HIF-2α was sufficient to inhibit proliferation, confirming their role as drivers of tumor cell survival and might reverse the potential resistance to concomitant mTor/HIF-1α inhibition in case of highly HIF-2α over-expression. The gene discussed is EPAS1; the disease is neoplasm.